A self-sufficient peroxide-driven hydroxylation biocatalyst

DOI: 10.1002/anie.200351434

Source and publish data:

Angewandte Chemie - International Edition p. 3299 - 3301 (2003)

Update date:2022-08-17

Topics:

Authors:

Cirino, Patrick C.

Arnold, Frances H.

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Article abstract of DOI:10.1002/anie.200351434

Directed evolution of the heme domain of cytochrome P450 BM-3 has resulted in a versatile, highly active peroxide-driven hydroxylation catalyst (see picture) that requires neither NADPH nor reductase and functions in a cell-free reaction system. This simplified, biomimetic catalyst is amenable to further optimization, for example, to improve stability or alter its substrate range.

Full text of DOI:10.1002/anie.200351434

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