Discovery of CYT997: a structurally novel orally active microtubule targeting agent

DOI: 10.1016/j.bmcl.2009.06.079

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 4639 - 4642 (2009)

Update date:2022-08-10

Topics:

Authors:

Burns, Christopher J.

Harte, Michael F.

Bu, Xianyong

Fantino, Emmanuelle

Joffe, Max

Sikanyika, Harrison

Su, Stephen

Tranberg, C. Elisabet

Wilson, Neil

Charman, Susan A.

Shackleford, David M.

Wilks, Andrew F.

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Article abstract of DOI:10.1016/j.bmcl.2009.06.079

CYT997 was discovered as a potent tubulin polymerization inhibitor possessing potent cytotoxic activity against a range of cancer cells. Details of SAR studies, pharmacokinetic investigations and synthesis of compounds leading to the discovery of CYT997 a

Full text of DOI:10.1016/j.bmcl.2009.06.079

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