Synthesis of side-chain functionalized amino acid derivatives through reaction of alkyl nitronates with α-bromoglycine derivatives

Article abstract of DOI:10.1016/0040-4020(95)00398-R

Reactions of alkyl nitronates with α-bromoglycine derivatives provide access to a variety of halo-, β-nitro- and α,β-dehydro-α-amino acid derivatives, including β-functionalized α,β-dehydroamino acid derivatives. The hydrochloride salts of free β-nitro-α-