Synthesis and Characterization of Neutral Technetium(III)-99 and 99m Complexes with O,P-Bidentate Phosphinocarboxylate Ligands. Crystal Structure of mer-*2Me2SO

DOI: 10.1039/DT9930002901

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Journal of the Chemical Society, Dalton Transactions p. 2901 - 2908 (1993)

Update date:2022-08-16

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Authors:

Refosco, Fiorenzo

Tisato, Francesco

Bandoli, Giuliano

Deutsch, Edward

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Article abstract of DOI:10.1039/DT9930002901

Reduction-substitution reactions of pertechnetate with a class of O,P-bidentate phosphinocarboxylic acid ligands HLⁿ afforded a series of neutral and paramagnetic n3> complexes.The products have been characterized by means of elemental analysis, IR, 1H NMR, UV/VIS and FAB mass spectroscopy, and X-ray crystallography for 23>.The latter crystallizes in the monoclinic space group P2₁/n with Z = 4, a = 21.718(10), b = 12.954(6), c = 18.038(9) Angstroem and β = = 106.59(4) deg.The final R value was 0.061.Three deprotonated chelates surround the metal in a distorted-octahedral environment adopting a meridional configuration, and consequently there are two pairs of like donor atoms trans to one another with the remaining phosphorus atom trans to an oxygen atom.Similar reduction-substitution reactions have been performed utilizing the short-lived isotope 99mTc.The physicochemical properties of the resulting 99mTc-labelled species match very well those exhibited by the analogues prepared with the long-lived isotope 99Tc.Thus the chemical structures of <99mTcLⁿ3> and <99Tcⁿ3> analogues are identical.Female Sprague-Dawley rats were injected with pre-purified <99mTcLⁿ3> (n = 1, 2 or 4) and the resulting biodistributions evaluated at different times post injection.All the complexes undergo very low, but significant, brain uptake which decreases with time.

Full text of DOI:10.1039/DT9930002901

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