Bioorganic and Medicinal Chemistry Letters p. 2395 - 2398 (1998)
Update date:2022-08-11
Topics:
Neustadt, Bernard R.
Smith, Elizabeth M.
Lindo, Neil
Nechuta, Terry
Bronnenkant, Alan
Wu, Arthur
Armstrong, Lydia
Kumar, Chandra
A set of biphenyl aminoacid building blocks has been synthesized. These were used to construct partially-peptidic combinatorial libraries as equimolar multi-component samples. Activity of members of this library as vitronectin receptor antagonists is described, together with SAR studies of the most active members. These studies illustrate several important features of combinatorial libraries.
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