Selective Inhibition of Trypanosomal Glyceraldehyde-3-phosphate Dehydrogenase by Protein Structure-Based Design: Toward New Drugs for the Treatment of Sleeping Sickness

DOI: 10.1021/jm00047a017

Source and publish data:

Journal of Medicinal Chemistry p. 3605 - 3613 (1994)

Update date:2022-08-17

Topics:

Authors:

Verlinde, Christophe L. M. J.

Callens, Mia

Calenbergh, Serge Van

Aerschot, Arthur Van

Herdewijn, Piet

et al. et al.

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Article abstract of DOI:10.1021/jm00047a017

Within the framework of a project aimed at rational design of drugs against diseases caused by trypanosomes and related hemoflagellate parasites, selective inhibitors of trypanosomal glycolysis were designed, synthesized, and tested.The design was based u

Full text of DOI:10.1021/jm00047a017

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