Tetrahedron p. 3669 - 3682 (1996)
Update date:2022-08-16
Topics:
Rajanna
Solomon, Florence
Moazzam Ali, Mir
Saiprakash
Kinetics of Vilsmeier-Haack reaction with o-hydroxy acetophenones (OHAP) have been investigated in different solvent systems comprising either a single component viz., dichloromethane (DGM), dichloroethane (DCE), acetonitrile (ACN), benzene or binary solvent mixtures of benzene and acetonitrile. The study revealed a total second order kinetics with a first order dependence on each of the [reactant] namely, [VH adduct] and [OHAP]. Increase in the dielectric constant (D) of the medium altered the rate of the reaction non linearly. The data did not fit into either Amis or Kirkwood's theories. These results were interpreted in terms of solvent-solute and solvent-cosolvent interactions. Structure-reactivity correlations have been explained by Hammett's equation.
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