COBALT-MEDIATED REACTIONS. A NEW SYNTHETIC APPROACH TO β-, χ- and δ-LACTAMS

Article abstract of DOI:10.1016/S0040-4039(00)99209-8

Unsaturated carbamylcobalt salophens, e.g. (2), undergo homolytic cleavage (heating, sunlamp) producing carbamyl radicals , viz (4) which then undergo cyclisation, accompanied by trapping (with Co^II or TEMPO) or dehydrocobaltation, leading to functionalised β-, χ-, and δ-lactams e.g. (3), (6), (8), (11), (13) and (16).