A short and efficient stereoselective synthesis of the potent 5- lipoxygenase inhibitor CMI-977

Article abstract of DOI:10.1080/00397910008087245

A short and efficient synthesis of the potent 5-lipoxygenase inhibitor CMI-977 is described using as the key step a stereoselective anomeric oxygen to carbon rearrangement of an alkynyl stannane tetrahydrofuranyl ether derivative mediated by boron trifluoride etherate.

Full text of DOI:10.1080/00397910008087245

Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic
Chemistry
ISSN: 0039-7911 (Print) 1532-2432 (Online) Journal homepage: http://www.tandfonline.com/loi/lsyc20
A Short and Efficient Stereoselective Synthesis of
the Potent 5-Lipoxygenase Inhibitor CMI-977
Darren J. Dixon , Steven V. Ley , Dominic J. Reynolds & Mukund S. Chorghade
To cite this article: Darren J. Dixon , Steven V. Ley , Dominic J. Reynolds & Mukund
S. Chorghade (2000) A Short and Efficient Stereoselective Synthesis of the Potent 5-
Lipoxygenase Inhibitor CMI-977, Synthetic Communications, 30:11, 1955-1961, DOI:
10.1080/00397910008087245
To link to this article: http://dx.doi.org/10.1080/00397910008087245
Published online: 04 Dec 2007.
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Date: 01 June 2016, At: 08:27