Substituted heterocyclic analogs as selective COX-2 inhibitors in the flosulide class

DOI: 10.1016/S0960-894X(98)00705-7

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 151 - 156 (1999)

Update date:2022-08-11

Topics:

Authors:

Ouimet, Nathalie

Chan, Chi-Chung

Charleson, Stella

Claveau, David

Gordon, Robert

Guay, Daniel

Chun-Sing, Li

Ouellet, Marc

Percival, David M.

Riendeau, Denis

Wong, Elizabeth

Zamboni, Robert

Prasit, Petpiboon

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Article abstract of DOI:10.1016/S0960-894X(98)00705-7

Substituted heterocyclic analogs in the Flosulide class were investigated as potential selective cyclooxygenase-2 inhibitors. 6-(4-Ethyl- 2-thiazolylthio)-5-methanesulfonamido-3H-isobenzofuran-1-one 14 was found to be the optimal compound in the series wi

Full text of DOI:10.1016/S0960-894X(98)00705-7

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