Bioorganic and Medicinal Chemistry Letters p. 151 - 156 (1999)
Update date:2022-08-11
Topics:
Ouimet, Nathalie
Chan, Chi-Chung
Charleson, Stella
Claveau, David
Gordon, Robert
Guay, Daniel
Chun-Sing, Li
Ouellet, Marc
Percival, David M.
Riendeau, Denis
Wong, Elizabeth
Zamboni, Robert
Prasit, Petpiboon
Substituted heterocyclic analogs in the Flosulide class were investigated as potential selective cyclooxygenase-2 inhibitors. 6-(4-Ethyl- 2-thiazolylthio)-5-methanesulfonamido-3H-isobenzofuran-1-one 14 was found to be the optimal compound in the series wi
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