Model studies related to CP-225,917: Stereocontrolled generation of the quaternary center

Article abstract of DOI:10.1016/S0040-4020(99)00712-7

The enolate derived from ester 15 reacts with diketone 10 stereoselectively (10:1), and the major isomer can be converted into lactone 21. This rearranges in boiling 1,2-dichlorobenzene to afford the tricyclic lactone 22, a model compound which shares wit