A new route to 2'-C-methylene nucleoside analogs, inhibitors of ribonucleotide reductase

DOI: 10.1016/0040-4039(95)00550-V

Source and publish data:

Tetrahedron Letters p. 3523 - 3526 (1995)

Update date:2022-08-28

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Authors:

Pontikis

Wolf Wolf

Monneret

Florent Florent

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Article abstract of DOI:10.1016/0040-4039(95)00550-V

Glycosyl phenyl sulfone obtained in 4 steps from isosaccharino-lactone was converted into a 2'-C-acetoxymethylfuranoid glycal with SmI₂-HMPA. Coupling of this glycal with silylated thymine or cytidine in the presence of Pd(0) led, after deprote

Full text of DOI:10.1016/0040-4039(95)00550-V

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