Total syntheses of natural occurring spermidine alkaloids: (+)-(2S)-Dihydrormyricoidine and (+)-(2S)-myricoidine

Article abstract of DOI:10.1016/S0040-4039(97)10568-8

The spermidine alkaloids (+)-(2S)-dihydromyricoidine (5) and (+)-(2S)-myricoidine (4) were synthesized under asymmetric conditions. The synthetic compounds 4 and 5 were found to have positive [α](D)²¹ values in both cases, which agrees with those of the natural alkaloids. Therefore the absolute configuration of the natural products are (2S)-configurated and not (2R)- as reported in the literature.