Facile synthesis of 2,2'-dichalcogenobis (N-alkyl/aryl benzenesulfonamides) from N-substituted benzenesulfonamides and the emergence of 2-alkyl 1,3,2-benzothiaselenazole 1,1 dioxides. Ebselen analogues

Article abstract of DOI:10.1016/S0040-4020(97)10240-X

A one pot synthesis of 2-2'-diselenobis/ditellurobis(N-alkyl/aryl benzenesulfonamides) 4a-h from N-alkyl/aryl benzenesulfonamides is elaborated. The first cyclization of 2-2'-diselenobis (N-methyl benzenesulfonamide) 4a into 2-methyl-1,3,2-benzothiaselenazole 1,1 dioxide (5a) using 3-chloroperoxybenzoic acid is described. Compounds 4a-h and 5a and d act as a new class of biologically active compounds.