Two new procedures for the introduction of benzyl-type protecting groups for thiols

Article abstract of DOI:10.1016/0040-4039(94)88305-X

Two new methods for the benzylation of thiols are described: a) direct-S- alkylation with para-substituted benzylic cations; and b) reductive S- alkylations of 2-aminothiols. Both methods provide efficient routes for the introduction of benzyl-type protecting groups in high yields.