Friedel-Crafts Reactions of 2-Amino-4-(alkyl or aryl)oxazoles with Acid Chlorides and Acid Anhydrides: Synthesis of 5-Acyl-2-amino-4-alkyloxazoles

Article abstract of DOI:10.1002/jhet.5570340237

Acid chlorides and anhydrides react with 2-amino-4-alkyloxazoles in the presence of aluminum chloride to produce 5-acyl substituted 2-amino-4-alkyloxazoles in modest yields. However, in the absence of the Lewis acid reaction occurs at the amino group to give the corresponding amides. This provides a viable entry for functionalising and making carbon-carbon bond at C-5 of this heterocyclic system.