Methanetricarboxylates as Key Reagents for the Simple Preparation of Heteroarylcarboxamides with Potential Biological Activity. Part 1 Reaction of Methanetricarboxylates with Indoline and 1,2,3,4-Tetrahydroquinoline

Article abstract of DOI:10.1002/jhet.5570340340

The reaction of methanetricarboxylates 2a,b with indoline as well as 1,2,3,4-tetrahydroquinoline yields tricyclic 4-hydroxy-2(1H)-quinolones with an ester group in position 3 (3, 8a,b). These heterocyclic esters condense with primary aliphatic, aromatic, and heteroaromatic amines to give the corresponding amides 5a-e and 10a-t.