Bioorganic and Medicinal Chemistry Letters p. 3193 - 3198 (1999)
Update date:2022-08-28
Topics:
Zhang, Xini
Bucala, Richard
A macrophage migration inhibitory factor (MIF) dopachrome tautomerization assay was employed for identification of MIF inhibitors. One group of dopachrome analogs was identified which inhibits MIF tautomerase activity. In particular, the analogs with a leaving group at β position displayed activity at a concentration of tenfold less than that of the MIF-substrate. These findings could lead to a better understanding of MIF biological activities and the development of agents for the treatment of MIF related diseases.
View More
Contact:+91 9963263336
Address:Plot#146A, IDA Mallapur, Hyderabad - 500072
Contact:18698110882
Address:1303 No2 building,LuoMa Garden,YongAn Road,Hexi District,Tianjin city
Anhui New Star Pharmaceutical Development Co., Ltd
Contact:013956922763
Address:Floor 3, F9A, F Workshop, No.110 Kexue Road, High-Tech Development Zone, Hefei, Anhui ,China
Hangzhou LINGEBA Technology Co., Ltd.
Contact:+0086-571-87389059
Address:Office 1-913,NewYouth Plaza, GongShu Area, HangZhou,ZheJiang,P.R.China
website:http://www.enbridgepharm.com
Contact:+86-510-83591909
Address:Huishan Zone, Wuxi City, Jiangsu Province, P.R.China
Doi:10.1515/hc-2013-0021
(2013)Doi:10.1007/BF00633187
(1988)Doi:10.1039/c39770000490
(1977)Doi:10.1016/j.tca.2006.04.010
(2006)Doi:10.1002/mrc.1260261103
(1988)Doi:10.1021/j150668a049
(1984)
