Selective Electrochemical Formyl Hydrogen-Exchange Fluorination of Aliphatic Aldehydes to Prepare Acyl Fluorides Using HF-Base Solutions

Article abstract of DOI:10.1246/cl.1994.849

The selective displacement of formyl hydrogen <-(C=O)-H> to fluorine in aliphatic aldehydes was successfully carried out electrochemically to give acyl fluorides in base-nHF (base: pyridine or Et3N, n=3-6) electrolyte solution with or without solvents such as acetonitrile and sulfolane.