Bioorganic and Medicinal Chemistry Letters p. 2677 - 2680 (1997)
Update date:2022-08-17
Topics:
Liu, David
Karanicolas, John
Yu, Catherine
Zhang, Zhihua
Woolley, G. Andrew
Syntheses of S-peptide analogues bearing phenylazophenylalanine (Pap) residues at positions 4, 8, and 11 are described. Noncovalent reassociation of the Pap-4 and Pap-11 peptides with S-protein reconstitutes ribonuclease activity. Photoisomerization of the Pap-4 peptide is found to modulate the enzyme activity.
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