An Improved Synthesis of O-Benzoyl Protected Hydroxamates

Article abstract of DOI:10.1021/jo971126q

Several primary amines (R-NH₂) were converted to their corresponding O-benzoyl protected hydroxamates under biphasic conditions. The intermediate (benzoyloxy)amines (R-NHOCOPh) were generated using benzoyl peroxide dissolved in CH₂Cl₂ and an aqueous carbonate buffer (pH 10.5) at room temperature. Subsequent acylation with R'COCl gave the protected hydroxamates (R'CONROCOPh) in good overall yields (56-89%).