Geometrically directed selective steroid hydroxylation with high turnover by a fluorinated artificial cytochrome P-450

Article abstract of DOI:10.1016/S0040-4039(98)00425-0

A metalloporphyrin has been synthesized carrying a beta-cyclodextrin group on tetrafluorophenyl rings at the four meso positions of the porphyrin. It performs the selective hydroxylation of an androstanediol derivative with complete positional selectivity