Facile addition of ketones to activated isoquinolines using N-methyl-2-pyrrolidinone

DOI: 10.1055/s-2007-965961

Source and publish data:

Synthesis p. 1077 - 1081 (2007)

Update date:2022-08-11

Topics:

Authors:

Yadav Yadav

Reddy Reddy

Gupta, Manoj K.

Prathap Prathap

Dash, Uttam

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Article abstract of DOI:10.1055/s-2007-965961

Ketones undergo a smooth addition to N-acylisoquinolinium ions in N-methyl-2-pyrrolidinone, under mild conditions, to produce 1-alkylated isoquinoline derivatives in excellent yields with high regioselectivity. The use of commercially available N-methyl-2

Full text of DOI:10.1055/s-2007-965961

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Product name:ethyl 1-(2-oxocyclohexyl)-1,2-dihydro-2-isoquinolinecarboxylate

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