Enantioselective synthesis of (1S,4R)-N-(benzylcarbamoyl)-4-aminocyclopent-2-en-1-ol by Candida antarctica lipase B

DOI: 10.1016/j.cclet.2015.07.005

Source and publish data:

Chinese Chemical Letters p. 1431 - 1434 (2015)

Update date:2022-08-29

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Authors:

Wen, Hui-Jiao

Chen, Qing

Zheng, Guo-Jun

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Article abstract of DOI:10.1016/j.cclet.2015.07.005

An efficient biocatalytic process has been developed to obtain optically pure (1S,4R)-N-(benzylcarbamoyl)-4-aminocyclopent-2-en-1-ol which can be used as the key intermediate of ticagrelor. In this research, several N-(benzylcarbamoyl)-4-aminocyclopent-2-

Full text of DOI:10.1016/j.cclet.2015.07.005

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Product name:carbamic acid, [(1r,4s)-4-hydroxy-2-cyclopenten-1-yl]-, phenylmethyl ester, rel- (9ci)

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