A facile synthesis of 5-N, N-bis(2-hydroxyethyl)amino-2- thiophenecarboxaldehyde

Article abstract of DOI:10.1080/00397910008087162

Amination of 5-bromo-2-thiophenecarboxaldehyde with an acyclic secondary amine - bis(2-methoxyethyl)amine was effected by using weak base sodium bicarbonate. The resulting 5-N,N-bis(2- methoxyethyl)amino-2-thiophenecarboxaldehyde was treated with boron tribromide to give 5-N,N-bis(2-hydroxyethyl)amino-2- thiophenecarbox-aldehyde.

Full text of DOI:10.1080/00397910008087162

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Synthetic Communications: An
International Journal for Rapid
Communication of Synthetic
Organic Chemistry
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A Facile Synthesis of 5-N, N-
Bis(2-Hydroxyethyl)Amino-2-
Thiophenecarboxaldehyde
Cheng Zhang a , Aaron W. Harper a , Darrell S. Spells
a & Larry R. Dalton a
a Department of Chemistry and Loker Hydrocarbon
Research Institute , University of Southern
California , Los Angeles, CA, 90089-1062 E-mail:
Published online: 04 Dec 2007.
To cite this article: Cheng Zhang , Aaron W. Harper , Darrell S. Spells & Larry
R. Dalton (2000) A Facile Synthesis of 5-N, N-Bis(2-Hydroxyethyl)Amino-2-
Thiophenecarboxaldehyde, Synthetic Communications: An International Journal
for Rapid Communication of Synthetic Organic Chemistry, 30:8, 1359-1364, DOI:
10.1080/00397910008087162
To link to this article: http://dx.doi.org/10.1080/00397910008087162
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Evaluation Only. Created with Aspose.PDF. Copyright 2002-2021 Aspose Pty Ltd.

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