Synthesis of pyrrolo[1,2-a]quinoxaline and its 4-(1-hydroxyalkyl) derivatives by Lewis acid-catalyzed reactions of 1-(2-isocyanophenyl)pyrrole

Article abstract of DOI:10.1246/cl.1998.551

When 1-(2-isocyanophenyl)pyrrole was treated with a catalytic amount of boron trifluoride, pyrrolo[1,2-a]quinoxaline was obtained almost quantitatively. The reaction in the presence of aldehydes or ketones gave the corresponding 4-(1-hydroxyalkyl)pyrrolo[1,2-a]quinoxalines in moderate to good isolated yields.