An efficient and convenient synthesis of 4-polyfluoroalkylated pyrrole-3-carboxylates through 1,3-dipolar cycloaddition reaction of polyfluoro-2-alkynoic acid esters with munchnones

Article abstract of DOI:10.1016/0022-1139(94)03180-8

1,3-Dipolar cycloaddition between polyfluoro-2-alkynoic acid esters and 1,3-oxazolium 5-olates (munchnones) readily proceeds in a regiospecific manner under very mild reaction conditions, followed by simultaneous decarboxylation to afford 4-(polyfluoroalk