Asymmetric nitrogen: 81. * diastereomeric derivatives of 1-alkoxy-2,2-bis(trifluoromethyl)aziridines. Structure and absolute configuration

Article abstract of DOI:10.1007/BF02495566

The ¹H NMR spectra of O-derivatives of 1-hydroxy-2,2-bis(trifluoromethyl)aziridine containing such substituents as EtO₂CCH₂, (R/S)-RO₂CCH(Me) (R = Me, Prⁱ, or Bu^t), (R/S)-H₂NC(O)CH(Me), and (R)-H₂NC(O)CH(Me) were analyzed. Both of the diastereomerically pure amides of the latter type were isolated. The validity of the ¹H NMR criteria, which were suggested for the determination of absolute configurations of diastereomers of N-alkoxyaziridines, was confirmed by X-ray diffraction study of the (R,R)-amide.