Photo-sensitized oxygenation of phenethylguanidoxime: A possible chemical model for the biological oxidation of Nω-hydroxy-L-arginine to L-citrulline

Article abstract of DOI:10.1016/0040-4039(96)00859-3

Photo-sensitized oxygenation of phenethylguanidoxime led to the effective production of an expected urea derivative along with generation of nitric oxide (NO) or its equivalent. The formation of both products could be reasonably explained by the mechanism based on singlet oxygen ene reaction of olefins. This should give a possible chemical model for the biological oxidation of Nω-hydroxy-L-arginine into L-citrulline and NO. Copyright