19F NMR non-equivalence of diastereomeric amides of 2,2,2-trifluoro-1-phenylethylamine

Article abstract of DOI:10.1016/S0040-4039(00)74468-6

An alternate synthesis and resolution is reported for 2,2,2-trifluoro-1-phenylethylamine. The ¹⁹F NMR of a series of amide derivatives of chiral acids is described. The diastereomeric non-equivalence of the ¹⁹F NMR signals (0.05-0.09 ppm) of these amides permits use of these derivatives for determination of enantiomeric purity of alpha-substituted acids. The potential for configurational correlations is discussed.