Tetrahedron Letters p. 847 - 848 (1994)
Update date:2022-08-18
Topics:
Wei, Zhong-Yong
Knaus, Edward E.
Magnesium methoxide is a simple, effective and highly selective reagent for the deprotection of N-alkoxycarbonyl lactams. The cleavage occurs via six-membered ring transition states involving coordination of magnesium ion with the oxygens of the carbamate and lactam carbonyl groups.
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