A novel, one-pot preparation of N-methyl-α-amino acid dipeptides from oxazolidinones and amino acids

Article abstract of DOI:10.1016/S0040-4039(98)02426-5

A new synthetic method has been developed to prepare N-methyl dipeptides in one-pot directly from oxazolidinones. Treatment of oxazolidinone 1 with an amino ester yields an intermediate N-hydroxymethyl dipeptide 3, which is treated with TFAA and triethyls