A New Synthesis of Muscone and Exaltone. The Enamine Approach of Ring-Enlargement Reaction

Article abstract of DOI:10.1002/hlca.19880710717

Key reaction in the synthesis of the title compounds in the treatment of the aldehydes 6 and 7 (obtained from 1) with a primary amine, e.g. pentylamine, in EtOH at room temperature.After stirring overnight, the products 8 and 9, respectively, are obtained in good yields.Both are enlarged by three ring members and can be transformed to Exalton (12) and (+/-)-muscone, (13), respectively.