Cyclo-saligenyl-5-fluoro-2′-deoxyuridinemonophosphate (cycloSal-FdUMP), A new prodrug approach for fdump

Article abstract of DOI:10.1080/07328319708006177

The synthesis of cycloSal-FdUMP 3a-d as a new prodrug approach for FdU 1 is described. Phosphotriesters 3 release the FdUMP 2 selectively by a controlled, chemically induced tandem reaction in hydrolysis studies. The biological activity (IC₅₀) of cycloSal-phosphotriesters 3 was evaluated in FM3A/O cells and FM3A/TK^- cells. Copyright

Full text of DOI:10.1080/07328319708006177

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Cyclo-saligenyl-5-fluoro-2′-
deoxyuridinemonophosphate
(cycloSal-FdUMP) — A New Prodrug
Approach for FdUMP
a
a
b
Martina Lorey , Chris Meier , Eric De Clercq & Jan Balzarini
b
a
Institute of Organic Chemistry, Johann Wolfgang Goethe-
University , Marie-Curie-Str.11, D-60439, Frankfurt am Main,
Germany
b
Rega Institute for Medical Research, Katholieke Universiteit
Leuven , B-3000, Leuven, Belgium
Published online: 16 Aug 2006.
To cite this article: Martina Lorey , Chris Meier , Eric De Clercq & Jan Balzarini (1997) Cyclo-
saligenyl-5-fluoro-2′-deoxyuridinemonophosphate (cycloSal-FdUMP) — A New Prodrug Approach
for FdUMP, Nucleosides and Nucleotides, 16:7-9, 1307-1310, DOI: 10.1080/07328319708006177
To link to this article: http://dx.doi.org/10.1080/07328319708006177
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