Organic Process Research and Development p. 587 - 592 (2004)
Update date:2022-08-18
Topics:
Scott, Robert W.
Fox, Darrell E.
Wong, John W.
Burns, Michael P.
Previously our group reported synthetic efforts used to synthesize kilogram quantities of the β-3 receptor agonist (R)-(4-(2-(2-(6-aminopyridin-3-yl)- 2-hydroxyethylamino)ethoxy)phenyl)-acetic acid, 1. Additional research was conducted to explore an alternate chiral route with a streamlined protecting group scheme. The alternate asymmetric process and synthetic rationale are described.
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