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REFERENCES
ACS Catalysis
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For the nickel-catalyzed decarbonylative coupling of am-
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For the nickel-catalyzed decarbonylative borylation of
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017). See the Supporting Information for details and a
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DynoChem®, by Scale-up Systems, is a leading process
development and scale-up software for scientists and engi-
neers working in the pharmaceutical industry and interfaces
directly with Microsoft Excel.
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For palladium-catalyzed C–C bond forming reactions of
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Reactions were performed in an inert atmosphere glove
box; aliquots were taken periodically and analyzed by SFC
using biphenyl as an internal standard in order to monitor
reaction progress. In general, five aliquots were taken per
experiment to chart the reaction profile.
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Lower catalyst loadings (i.e., entries 4 and 5) were run at
higher temperatures and concentrations solely to achieve
conversion in a reasonable timeframe.
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Although the kinetic model can itself provide insight into
possible mechanistic steps, it is helpful to have some un-
derstanding of the mechanism of the reaction in question
prior to optimization.
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See the Supporting Information for details.
Although the esterification of benzamide 1 with (–)-
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339. (l) Cui, M.; Wu, H.; Jian, J.; Wang, H.; Liu, C.;
menthol (2) could be optimized further, conditions using
Stelck, D.; Zeng, Z. Chem. Commun. 2016, 52, 12076–
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