Steroids p. 281 - 290 (1981)
Update date:2022-08-11
Topics:
Simons, S. Stoney
Merchlinsky, Michael J.
Johnson, David F.
A new, base-catalyzed cleavage of C21-steroids to give 17-ketosteroids is described.This reaction is specific for those steroids containing the C-17-dihydroxy acetone side chain.In the presence of oxygen, these same reaction conditions readily degrade corticosterone to the 17β-carboxylic acid.
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