
Tetrahedron p. 521 - 524 (1980)
Update date:2022-08-29
Topics:
Kulstad, S.
Malmsten, L. A.
The mechanism of the formation of 1,7,10,16-tetraoxa-4,13-diazacyclooctadecane has been studied from both a thermodynamic and a kinetic point of view.The cyclisation is favoured by the presence of an alkali metal ion, which forms a complex with the ring precursor.Both this intermediate and the complex react with starting material, but only the complex forms a cyclic product.The rate constants of these reactions have been determined by using simulation methods.
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