New chiral borohydride based reducing agent: Asymmetric reduction of 9-anthryl trifluoromethyl ketone and other carbonyl compounds

Article abstract of DOI:10.1080/00397919808005078

(S)-(+)-2-(α-Hydroxybenzyl)benzimidazole and (S)-(-)-2-benzimidazole-1-ethanol were synthesised and converted to chiral borohydrides which reduced prochiral ketones to the corresponding chiral alcohols in high yields (80 to 100%, e.e. 42 to 95%). This is the first report of sodium borohydride modified by 1,2-amino alcohol.

Full text of DOI:10.1080/00397919808005078

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Synthetic Communications: An
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New Chiral Borohydride Based
Reducing Agent: Asymmetric
Reduction of 9-Anthryl
Trifluoromethyl Ketone and
Other Carbonyl Compounds
a
a
Dilip K. Maiti & Pranab K. Bhattacharya
a
Medicinal Chemistry Division, Indian Institute
of Chemical Biology, 4 Raja S.C. Mullick Road,
Calcutta, 700 032, INDIA
Version of record first published: 20 Aug 2006.
To cite this article: Dilip K. Maiti & Pranab K. Bhattacharya (1998): New
Chiral Borohydride Based Reducing Agent: Asymmetric Reduction of 9-Anthryl
Trifluoromethyl Ketone and Other Carbonyl Compounds, Synthetic Communications:
An International Journal for Rapid Communication of Synthetic Organic Chemistry,
28:1, 99-108
To link to this article: http://dx.doi.org/10.1080/00397919808005078
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