Journal of Organic Chemistry p. 15958 - 15971 (2019)
Update date:2022-08-10
Topics:
Zhang, Pengpeng
Li, Yuanhe
Yan, Zhiming
Gong, Jianxian
Yang, Zhen
The development of an efficient strategy for the asymmetric total synthesis of the bioactive marine natural product (-)-pavidolide B is described in detail. The development process and detours leading to the key thiyl-radical-mediated [3 + 2] annulation reaction, which constructed the central C ring with four contiguous stereogenic centers in one step, are depicted. Subsequently, the seven-membered D ring is constructed via a ring-closing metathesis reaction followed by a Rh(III)-catalyzed isomerization. This strategy enables the total synthesis of (-)-pavidolide B in the longest linear sequence of 10 steps.
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