Systematic Substitution on the Cubane Nucleus: Steric and Electronic Effects

Article abstract of DOI:10.1021/jo00041a038

Effective methodology for the synthesis of cubanes with novel substitution patterns is presented.The use of an electron-withdrawing group to accelerate ortho-metalation of amide-activated cubanes is described, as is the effect of the steric bulk of the activating group on the degree of ortho-metalation.