Clearance and analgesic activity of the quaternized opiate, N-methyl-morphine [6-3H] administered intracisternally to the rat

Article abstract of DOI:10.1111/j.2042-7158.1978.tb13196.x

The authors report on the preparation, clearance and analgesic activity of N-methylmorphine [6-³H] administered intracisternally to the rat and show that the analgesia is due to the quaternary compound and not to an in vivo conversion to the te