Purines, pyrimidines, and fused systems based on them 16. Oxidative animation of 6,8-dimethylpyrimido[4,5-c]pyridazine-5,7(6H,8H)-dione

Article abstract of DOI:10.1007/BF02496020

6,8-Dimethylpyrimido[4,5-c)pyridazine-5,7(6H,8H)-dione reacts with ammonia or primary amines in the presence of an oxidant to give the corresponding 4-amino derivatives. Reactions with secondary amines (dimethylamine, piperidine, or morpholine) proceed wi