Bioorganic and Medicinal Chemistry Letters p. 3261 - 3266 (1999)
Update date:2022-08-12
Topics:
Satz, Alexander L.
Bruice, Thomas C.
A new type of microgonotropen that fluoresces upon binding to dsDNA has been synthesized. FMGT-1, an analogue of the minor groove binder Hoechst 33258, is functionalized with a polyamine chain capable of interacting with the phosphate backbone of DNA. Binding studies indicate that FMGT-1 binds more tightly to dsDNA than the parent compound Hoechst 33258.
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