Stereoselective radical addition of tertiary amines to (5R)-5- menthyloxy-2[5H]-furanone: Application to the enantioselective synthesis of (-)-isoretronecanol and (+)-labumine

Article abstract of DOI:10.1016/S0040-4039(99)00452-9

The adducts of a stereoselective radical addition of tertiary amines with (5R)-5-menthyloxy-2[5H]-furanone were transformed very efficiently into enantiomerically pure pyrrolizidine and indolizidine alkaloids, through a three steps sequence.