Chiral Synthesis of (-)-Colletol Based on Palladium-Catalyzed Reductive Cleavage of Alkenyloxiranes with Formic Acid

Article abstract of DOI:10.1246/cl.1993.1759

Total synthesis of (-)-colletol was achieved using palladium-catalyzed hydrogenolysis of optically active (E)-4,5-epoxy-2-alkenoates to (E)-5-hydroxy-2-alkenoates with formic acid as a key step for preparation of the intermediate hydroxy ester segments.