Phosphodisulfide bond: A new linker for the oligonucleotide conjugation

DOI: 10.1016/S0040-4039(98)01854-1

Source and publish data:

Tetrahedron Letters p. 8271 - 8274 (1998)

Update date:2022-08-11

Topics:

Authors:

Chassignol, Marcel

Thuong, Nguyen T.

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Article abstract of DOI:10.1016/S0040-4039(98)01854-1

Oligonucleotide thiophosphates react with 2-pyridyl-disulfide derivatives to give phosphodisulfide which can, upon reduction, be easily cleaved to give the starting oligonucleotide with a terminal thiophosphate group.

Full text of DOI:10.1016/S0040-4039(98)01854-1

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