A practical synthesis of 2-butyl-4(5)-chloro-5(4)-hydroxymethyl-1H-imidazole

Article abstract of DOI:10.1080/00397919308012598

A practical process for the synthesis of 2-butyl-4-hydroxymethyl imidazole (4) followed by chlorination to provide chloroimidazole 1 in an overall 71% yield has been developed.

Full text of DOI:10.1080/00397919308012598

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Synthetic Communications: An
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Organic Chemistry
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A Practical Synthesis of
2-Butyl-4(5)-chloro-5(4)-
hydroxymethyl- 1H-imidazole
Yao-Jun Shi a , Lisa F. Frey a , David M. Tschaen a
Thomas R. Verhoeven a
&
a Department of Process Research, Merck Research
Laboratory, P.O. Box 2000, Rahway, New Jersey,
07065
Published online: 24 Sep 2006.
To cite this article: Yao-Jun Shi , Lisa F. Frey , David M. Tschaen & Thomas R.
Verhoeven (1993): A Practical Synthesis of 2-Butyl-4(5)-chloro-5(4)-hydroxymethyl-
1H-imidazole, Synthetic Communications: An International Journal for Rapid
Communication of Synthetic Organic Chemistry, 23:18, 2623-2630
To link to this article: http://dx.doi.org/10.1080/00397919308012598
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