Journal of Heterocyclic Chemistry p. 1065 - 1066 (1997)
Update date:2022-08-11
Topics:
Varkonyi-Schlovicsko, Erika
Takacs, Kalman
Hermecz, Istvan
Diastereomeric timolol tartrates 4 are obtained in a one-pot synthesis from the racemic base 2 and optically active O,O-diacetyl- or O,O,- dibenzoyltartaric anhydrides 3, as only one of the diastereomers precipitates from acetone solution. Acidic hydrolysis as the corresponding 4 leads to timolol in high yield and optical purity.
View More
Contact:+86-20-89089654/ 89089744
Address:Poly World Trade Center C Tower 12 Floor 1211 Room No. 1000 Xingangdong Road Haizhu District Guangzhou 510305 Guangdong province China
Sichuan Highlight Fine Chemicals Co., Ltd.
Contact:+86-28-8525 1605
Address:A5-102 Airport base,388 West Airport Huang He Zhong Lu,2 Section
Shanghai Coupling Pharmaceutical R&D Co., Ltd.(expird)
Contact:+86 021 50106671
Address:403 Room No.4 Buiding, No. 526 Ruiqing Road, Shanghai Zhangjiang Hi-Tech Park
Guangzhou Puho Pharmaceutical Technology Co. Ltd.
Contact:86-20-29848035/29848075
Address:No.166, Chaoyang East Road, Panyu District, Guangzhou City, Guangdong Province
Hangzhou Hysen Pharma co.,Ltd.
website:http://www.hysenpharma.cn/
Contact:0086-571-88298791
Address:#701,Gudun Road Hangzhou
Doi:10.1081/CAR-120025325
(2003)Doi:10.1021/j100409a032
(1986)Doi:10.1016/S0040-4039(00)70006-2
(1966)Doi:10.1139/v65-066
(1965)Doi:10.3762/bjoc.12.153
(2016)Doi:10.1002/hc.20354
(2008)
