Journal of Heterocyclic Chemistry p. 1065 - 1066 (1997)
Update date:2022-08-11
Topics:
Varkonyi-Schlovicsko, Erika
Takacs, Kalman
Hermecz, Istvan
Diastereomeric timolol tartrates 4 are obtained in a one-pot synthesis from the racemic base 2 and optically active O,O-diacetyl- or O,O,- dibenzoyltartaric anhydrides 3, as only one of the diastereomers precipitates from acetone solution. Acidic hydrolysis as the corresponding 4 leads to timolol in high yield and optical purity.
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