Lipase catalyzed diastereoselective deacetylations of anomeric mixtures of peracetylated 2'-deoxynucleosides

Article abstract of DOI:10.1080/15257779408009482

Lipase catalyzed deacetylations of anomeric mixtures of peracetylated 2'- deoxyribofuranosyl- and 2'-deoxyribopyranosyl thymine nucleosides 1 and 5 have been investigated. Generally, the diastereoselectivity was more pronounced in pure phosphate buffer than in phosphate buffer containing 10% DMF. Wheat Germ Lipase and Porcine Liver Esterase catalyzed diastereoselective deacetylation of 1 affording the pure β-anomer thymidine (4β) as the only completely deprotected nucleoside product.

Full text of DOI:10.1080/15257779408009482

This article was downloaded by: [New York University]
On: 01 June 2015, At: 02:04
Publisher: Taylor & Francis
Informa Ltd Registered in England and Wales Registered Number: 1072954 Registered
office: Mortimer House, 37-41 Mortimer Street, London W1T 3JH, UK
Nucleosides and Nucleotides
Publication details, including instructions for authors and
subscription information:
http://www.tandfonline.com/loi/lncn19
Lipase Catalyzed Diastereoselective
Deacetylations of Anomeric Mixtures of
Peracetylated 2′-Deoxynucleosides
a
a
a
D. L. Darmkjaer , M. Petersen & J. Wengel
a
Department of Chemistry , Odense University , DK-5230, Odense M,
Denmark
Published online: 24 Sep 2006.
To cite this article: D. L. Darmkjaer , M. Petersen & J. Wengel (1994) Lipase Catalyzed
Diastereoselective Deacetylations of Anomeric Mixtures of Peracetylated 2′-Deoxynucleosides,
Nucleosides and Nucleotides, 13:8, 1801-1807, DOI: 10.1080/15257779408009482
To link to this article: http://dx.doi.org/10.1080/15257779408009482
PLEASE SCROLL DOWN FOR ARTICLE
Taylor & Francis makes every effort to ensure the accuracy of all the information (the
“
Content”) contained in the publications on our platform. However, Taylor & Francis,
our agents, and our licensors make no representations or warranties whatsoever as to
the accuracy, completeness, or suitability for any purpose of the Content. Any opinions
and views expressed in this publication are the opinions and views of the authors,
and are not the views of or endorsed by Taylor & Francis. The accuracy of the Content
should not be relied upon and should be independently verified with primary sources
of information. Taylor and Francis shall not be liable for any losses, actions, claims,
proceedings, demands, costs, expenses, damages, and other liabilities whatsoever or
howsoever caused arising directly or indirectly in connection with, in relation to or arising
out of the use of the Content.
This article may be used for research, teaching, and private study purposes. Any
substantial or systematic reproduction, redistribution, reselling, loan, sub-licensing,
systematic supply, or distribution in any form to anyone is expressly forbidden. Terms &
Conditions of access and use can be found at http://www.tandfonline.com/page/terms-
and-conditions